1Prostaglandin E Signaling and Bacterial Infection Recruit Tumor-Promoting Macrophages to Mouse Gastric Tumors日本金沢大学癌症研究所Gastroenterology 12.9EphB32RN181 suppressed tumor growth of hepatocellular carcinoma by inhibition of the ERK/MAPK pathway南方医科大学Hepatology10.8activated caspase3 bs70043Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways.  清华大学Blood  10.6 BS1620 TfR1  BS3547 Lamin B1 4D-peptide inhibitors of the p53–MDM2 interaction for targeted molecular therapy of malignant neoplasms美国马里兰大学PNAS9.4p53 and MDM25New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis河北医科大学J Hepatol7.8MMP-1 and MMP-136PDK1 Regulates Vascular Remodeling and Promotes Epithelial-Mesenchymal Transition in Cardiac Development南京大学模式动物研究所molecular and cellular biology7.8BS1853 SNAI 17Endothelial cells dysfunction induced by silica nanoparticles through oxidative stress via JNK/P53 and NF-kB pathways上海交通大学Biomaterials7.4p-ERK, ERK, p-JNK, JNK, p-c-Jun, c-Jun8HOXB7 as a prognostic factor and mediator of colorectal cancer progression南方医科大学Clinical Cancer Research6.7p-ERK, ERK, p-AKT, AKT, p-GSK3β, GSK3β, Cyclin D1 and P27 antibodies (Bioworld Technology, MN).9Endostatin inhibits tumour lymphangiogenesis and lymphatic metastasis via cell surface nucleolin on lymphangiogenic endothelial cells清华大学J Pathol6.5BS1574 PECAM-110Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/b-Catenin Signaling上海交通大学journal of bone and mineral research6.0BS5056 p-beta-catenin (S33 S37 T41)11UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation 中科院上海生命科学研究所Mol Biol Cell6.0BS1387 Caspase-8、BS1478 TNFR112Trio Is a Key Guanine Nucleotide Exchange Factor Coordinating Regulation of theMigration andMorphogenesis of Granule Cells in the Developing Cerebellum南京大学模式动物研究所journal of biological chemistry5.3Tau13Heme Oxygenase-1/Carbon Monoxide Induces Vascular Endothelial Growth Factor Expression via p38 Kinase-dependent Activation of Sp1台湾医学科学院journal of biological chemistry5.3phospho-Sp1-T739 antibody (BS4755)14Slow skeletal muscle myosin binding protein-C (MyBPC1) mediates recruitment of muscle type creatine kinase (CK) to myosin.清华大学Biochemical Journal Immediate Publication5.1MM-CK BS191515Silencing of hHS6ST2 inhibits progression of pancreatic cancer through inhibition of Notch signaling中国药科大学Biochemical Journal Immediate Publication5.1CD3116Common genetic variants on 8q24 contribute to susceptibility to bladder cancer in a Chinese population南京医科大学Carcinogenesis4.8MYC17Mitochondrial Prohibitins and Septin 9 Are Implicated in the Onset of Rat Hepatocarcinogenesis日本大阪市立大学医学部Toxicological Sciences 4.8BS1992 HNF-4αγ18miR-106a–mediated Malignant Transformation of Cells Induced by Anti-benzo [a] pyrene-trans-7, 8-diol-9, 10-epoxide. 广州医科大学Toxicol Sci4.8RB GAPDH19Increase of Anteroventral Periventricular Kisspeptin Neurons and Generation of E2-Induced LH-Surge System in Male Rats Exposed Perinatally to Environmental Dose of Bisphenol-A. 南京医科大学Endocrinology4.8Biotin goat anti mouse20miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines南京医科大学International Journal of Cancer4.7BCL2, b-actin and a-Tubulin21Adenoviral-mediated RNA interference targeting URG11 inhibits growth of human hepatocellular carcinoma第四军医大学International Journal of Cancer4.7pRb BS416422Lymphatic endothelial cell-secreted CXCL1 stimulates lymphangiogenesis and metastasis of gastric cancer中山大学International Journal of Cancer4.7Rho A23p53 suppresses lung resistance-related protein expression through Y-box binding protein 1 in the MCF-7 breast tumor cell line北京放射医学研究所Journal of Cellular Physiolo4.6anti-HDAC22417b-Estradiol Enhances the Response of Plasmacytoid Dendritic Cell to CpG南京大学PLoS ONE4.3BS1754 IFN-αβRα25LRP16 Integrates into NF-kB Transcriptional Complex and Is Required for Its Functional Activation解放军总医院PLoS ONE4.3CARM1,P300/CBP 26Mechanisms involved in extraterritorial facial pain following cervical spinal nerve injury in rats日本大学牙医部Molecular Pain4.1BS5090 p-NMDAR1 (S896)27proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells. 日本东京医科齿科大学Lung Cellular and Molecular Physiology 4.0MMP-13 BS123828Luteolin inhibits inflammatory response and improves insulin sensitivity in the endothelium中国药科大学Biochimie3.9P-IRS-1、IRS-1、P-AKT、AKT、P-IKK、IKK、horseradish peroxidase (HRP)-labeled anti-rabbit IgG 29DHEA prevents A 25e35-impaired survival of newborn neurons in the dentate gyrus through a modulation of PI3K-Akt-mTOR signaling南京医科大学Neuropharmacology3.9phosphor p70S6k、p70S6k3020(S)-Ginsenoside Rh2 Noncompetitively Inhibits P-Glycoprotein In Vitro and In Vivo: A Case for Herb-Drug Interactions中国药科大学Drug Metabolism and Disposition3.7BS6007M β-Actin mAb31Local hyperthermia could induce antiviral activity by endogenous interferon-dependent pathway in condyloma acuminata中国医科大学Antiviral Research3.6PKR、Stat1、Stat232Plasma Membrane H+-ATPase and 14-3-3 Isoforms of Arabidopsis Leaves: Evidence for Isoform Specificity in the 14-3-3/H+ -ATPase Interaction瑞典兰德大学Plant Cell Physiol3.6anti 14-3-333Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-kB activation中国药科大学Neurochemistry International3.5p-p65,p65,p-IKKb,IKK,IkBa,p-IkBa,akt,p-akt,p-ERK,ERK34Loganin protects against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1/2 MAPKs in SH-SY5Y cells韩国成均馆大学Neurochemistry International3.5Rabbit anti-JNK and rabbit anti-ERK 1/2 MAPKs antibodies35Involvement of p120 in LPS-induced NF- B activation and IL-8 production in human bronchial epithelial cells华中科技大学Toxicology Letters3.5Phosphorylated IkB a(S32 + S36)36Involvement of JNK and P53 Activation in G2/M Cell Cycle Arrest and Apoptosis induced by Titanium Dioxide Nanoparticles in neuron cells上海交通大学Toxicology Letters3.5p-JNK, JNK, p-c-Jun, c-Jun、p-p53、bcl2、bax37A sensitive immunoassay based on direct hapten coated format and biotin-streptavidin system for the detection of chloramphenicol华中农业大学Talanta3.3HRP-SPA?38Interleukin-15 receptor-directed immunotoxins atteunuate disease severity in rat adjuvant arthritis东南大学Molecular Immunology3.2phosphotyrosine STAT3、STAT339Slit2-N inhibits PDGF-induced migration in rat airway smooth muscle cells:WASP and Arp2/3 involved第二军医大学Toxicology3.2WASP40Gambogic acid-induced degradation of mutant p53 is mediated by proteasome and related to CHIP 中国药科大学Journal of Cellular Biochemistry3.0Hsp90、ubiquitin41PI3K and ERK/Nrf2 pathways are involved in oleanolic acid-induced heme  oxygenase-1 expression in rat vascular smooth muscle cells 第三军医大学Journal of Cellular Biochemistry3.0Akt and p-Akt42HSP75 protects against cardiac hypertrophy and fibrosis武汉人民医院Journal of Cellular Biochemistry3.0MB001 GAPDH43Mutational and expressional analysis of RFC3,a clamp loader in DNA replication, in gastric and colorectal cancers韩国天主教大学Human Pathology3.0RFC344Cdk1 is required for the self-renewal of mouse embryonic stem cells首都师范大学J Cell Biochem2.9Cdk145LPA Rescues ER Stress-Associated Apoptosis in Hypoxia and Serum Deprivation-Stimulated
Mesenchymal Stem Cells医科院阜外医院J CELL BIOCHEM2.9p-eIF2a and  eIF2a46Ghrelin-Attenuated Cognitive Dysfunction in Streptozotocin-induced Diabetic Rats.(全文暂无)美国德克萨斯大学Alzheimer Disease & Associated Disorders2.9p-ERK1/247Effects of the acid polysaccharide fraction isolated from a cultivated Cordyceps sinensis on macrophages in vitro南京大学Cellular Immunology2.7NF-kBp65 monoclonal写成单抗了48Specific Role of Tight Junction Proteins Claudin-5, Occludin,and ZO-1 of the Blood–Brain Barrier in a Focal Cerebral Ischemic Insult中国医科大学J Mol Neurosci2.7rabbit anti-PKCδ(diluted 1:500; Bioworld)49The regulatory mechanism of Hsp90a secretion from endothelial cells and its role in angiogenesis during wound healing清华大学BBRC2.6BS1574 PECAM-150Differentiation of mouse embryonic stem cells into dental epithelial-like cells induced by ameloblasts serum-free conditioned medium第四军医大学BBRC2.6CK1451Roles of Wnt/b-catenin signaling in epithelial differentiation of mesenchymal stem cells南京大学医学院BBRC2.6GSK3b, pi-GSK3b, catenin-b, pi-catenin-b、TCF352Transmission of circulating cell-free AA amyloid oligomers in exosomes vectors via a prion-like mechanism日本熊本大学BBRC2.6Tsg101 53hCLP46 regulates U937 cell proliferation via Notch signaling pathway中国科学院生命科学学院BBRC2.6p-Rb (S780) pAb54Anti-invasive effect of gambogic acid in MDA-MB-231 human breast carcinoma cells中国药科大学Biochem Cell Biol2.6ERK1 255Cryptotanshinone has diverse eVects on cell cycle events in melanoma cell lines with diVerent metastatic capacity南京中医药大学Cancer Chemother Pharmacol2.6BS1053 Chk1、BS1391 Chk2、BS1804 Cyclin A1、BS1820 Cdk1Cdc256Synergistic effect of 5-fluorouracil and the flavanoid oroxylin A on HepG2 human hepatocellular carcinoma and on H22 transplanted mice中国药科大学Cancer Chemother Pharmacol2.6COX-257Gambogenic acid mediated apoptosis through the mitochondrial oxidative stress and inactivation of Akt signaling pathway in human nasopharyngeal carcinoma CNE-1 cells安徽中医药大学European Journal of Pharmacology2.6caspase-958Dexamethasone enhances trichosanthin-induced apoptosis in the HepG2 hepatoma cell line浙江大学药学院Life Sciences2.6histone H159Association of Elevated GRP78 Expression with Increased Astrocytoma Malignancy via Akt and ERK Pathways第四军医大学Brain Research2.5GRP7860Peroxisome proliferator-activated receptor gamma agonist rosiglitazone attenuates oxyhemoglobin-induced Toll-like receptor 4 expression in vascular smooth muscle cells南京大学Brain Research2.5TLR461MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and1uPAR expression via HOXD10南京医科大学Brain Research2.5HRP-conjugated rabbit anti-goat secondary antibodies62Effect of CIPC and intervention of Ca2+-regulated factors on CaN, cbl-b and p-AKT expression in neurons大连医科大学Brain Research2.5AKT、p-AKT63Sorafenib Induces Growth Inhibition and Apoptosis of Human Chondrosarcoma Cells by Blocking the RAF/ERK/MEK Pathway北京人民医院Journal of Surgical Oncology2.51032Bcl-xl、1220Mcl-1、1310Rb64NGF/TrkA-mediated Kidins220/ARMS signaling activated in the allergic airway challenge in mice 中国医科大学Ann Allergy Asthma Immunol2.4CrkL65Angiotensin Type-1 Receptor Blocker Candesartan Inhibits Calcium Oxalate Crystal Deposition in Ethylene Glycol-Treated Rat Kidneys日本大阪大学 Urology2.4TGF-β66Japanese encephalitis virus co-opts the ER-stress response protein GRP78 for viral infectivity台湾长庚大学Virology Journal2.4anti-GRP7867Modified Si-Miao-San Extract inhibits inflammatory response and modulates insulin sensitivity in hepatocytes through an IKKβ/IRS-1/Akt-dependent pathway中国药科大学Journal of Ethnopharmacology2.3pIKKb pIRS IRS pAKT AKT68Modified Si-Miao-San extract inhibits the release of inflammatory mediators from lipopolysaccharide-stimulated mouse macrophages中国药科大学Journal of Ethnopharmacology2.3IKB-a69Involvement of p38 MAPK signaling pathway in the anti-melanogenic effect of San-bai-tang, a Chinese herbal formula, in B16 cells香港浸会大学Journal of Ethnopharmacology2.3tyrosinase, MITF and TRP-270Integral pharmacokinetics of multiple lignan components in normal, CCl4-induced hepatic injury and hepatoprotective agents pretreated rat sand correlations with hepatic injury biomarkers中国药科大学Journal of Ethnopharmacology2.3发光液ECL71Ursolic acid induces HL60 monocytic differentiation and upregulates C/EBPb expression by ERK pathway activation中国药科大学Anti-Cancer Drugs2.2anti-C/EBPb and anti-c-myc 72Retinoic acid attenuates lipopolysaccharide-induced inflammatory responses by suppressing TLR4/NF-κB expression in rat mammary tissue南京农业大学International Immunopharmacology2.2GAPDH73Inhibitory effect of siRNA targeting IGF-1R on endometrial carcinoma中山大学International Immunopharmacology2.2Ki6774Flavonoids, apigenin and icariin exert potent melanogenic activities in murine B16 melanoma cells香港浸会大学Phytomedicine2.2tyrosinase and TRP-275Tanshinone II A attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression浙江大学 Phytomedicine2.2 Troponin I76The neuroprotective effects of Lonicera japonica THUNB. against hydrogen peroxide-induced apoptosis via phosphorylation of MAPKs and PI3K/Akt in SH-SY5Y cells韩国成均馆大学Food and Chemical Toxicology2.1Rabbit anti-JNK and rabbit anti-ERK 1/2 MAPKs antibodies77c-Jun N-terminal kinase is involved in the regulation of proliferation and apoptosis by integrin-linked kinase in human retinoblastoma cells武汉大学Graefes Arch Clin Exp Ophthalmol2.1p-JNK JNK P-c-JUN c-JUN 78Cordyceps sinensis Extracts Attenuate Aortic Transplant Arteriosclerosis in Rats温州医学院Journal of Surgical Research2.1PCNA79Double antioxidant activities of rosiglitazone against high glucose-induced oxidative stress in hepatocyte第四军医大学Toxicology in Vitro2.1P-PKC,  PKC,  COX-2,  PPAR ,  and  p38  MAPK 80Signal transduction mechanism of TRB3 in rats with non-alcoholic fatty liver disease上海长宁中心医院World Journal of Gastroenterology2.1Akt (A444) , p-Akt (S473) and p-Akt (T308)81Nuclear Factor-Kappa B Activity Regulates Brain Expression of P-Glycoprotein in the Kainic Acid-Induced Seizure Rats南京医科大学Mediators of Inflammation2.0anti phospho-NF-κB p65 BS413582Inhibition of vascular endothelial growth factor-induced angiogenesis by scopoletin through interrupting the autophosphorylation of VEGF receptor 2 and its downstream signaling pathways中国药科大学Vascular Pharmacology2.0p-VEGFR1, p-VEGFR2, VEGFR1, VEGFR2, p-AKT，AKT, p-eNOS and eNOS